Antidepressants are medicines that are used to treat clinical depression. Antidepressants are often used in conjunction with other types of therapy, such as psychological or behavioral therapy. Depression does not mean feeling down for some days. Instead, it is a disease that lasts for a longer time and affects a person's overall life. There are different types of antidepressants. Tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), serotonin reuptake inhibitors (SSRIs), and atypical antidepressants are the four primary groups of antidepressants.